1W8K

Crystal structure of apical membrane antigen 1 from Plasmodium vivax

1W8K の概要

• エントリーDOI: 10.2210/pdb1w8k/pdb
• 関連するPDBエントリー: 1W81
• 分子名称: APICAL MEMBRANE ANTIGEN 1, IMIDAZOLE (3 entities in total)
• 機能のキーワード: plasmodium antigen, malaria vaccine candidate, antigen
• 由来する生物種: PLASMODIUM VIVAX
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51666.13

構造登録者

Pizarro, J.C.,Vulliez-Le Normand, B.,Chesne-Seck, M.-L.,Kocken, C.H.M.,Thomas, A.W.,Bentley, G.A. (登録日: 2004-09-23, 公開日: 2005-03-01, 最終更新日: 2024-11-13)

主引用文献

Pizarro, J.C.,Vulliez-Le Normand, B.,Chesne-Seck, M.-L.,Collins, C.,Withers-Martinez, C.,Hackett, F.,Blackman, M.,Faber, B.,Remarque, E.,Kocken, C.H.M.,Thomas, A.W.,Bentley, G.A.
Crystal Structure of the Malaria Vaccine Candidate Apical Membrane Antigen 1
Science, 308:408-, 2005

PubMed Abstract: Apical membrane antigen 1 from Plasmodium is a leading malaria vaccine candidate. The protein is essential for host-cell invasion, but its molecular function is unknown. The crystal structure of the three domains comprising the ectoplasmic region of the antigen from P. vivax, solved at 1.8 angstrom resolution, shows that domains I and II belong to the PAN motif, which defines a superfamily of protein folds implicated in receptor binding. We also mapped the epitope of an invasion-inhibitory monoclonal antibody specific for the P. falciparum ortholog and modeled this to the structure. The location of the epitope and current knowledge on structure-function correlations for PAN domains together suggest a receptor-binding role during invasion in which domain II plays a critical part. These results are likely to aid vaccine and drug design.

PubMed: 15731407
DOI: 10.1126/SCIENCE.1107449

実験手法

X-RAY DIFFRACTION (1.8 Å)