1W5Z

AGAO covalent complex with Benzylhydrazine

1W5Z の概要

• エントリーDOI: 10.2210/pdb1w5z/pdb
• 関連するPDBエントリー: 1W6C 1W6G
• 分子名称: PHENYLETHYLAMINE OXIDASE, COPPER (II) ION, SODIUM ION, ... (6 entities in total)
• 機能のキーワード: amine oxidase, arthrobacter globiformis, copper containing, metal-binding, oxidoreductase, tpq, quinone, inhibited, bh, benzylhydrazine, 3ty
• 由来する生物種: ARTHROBACTER GLOBIFORMIS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 72703.12

構造登録者

Duff, A.P.,Trambaiolo, D.M.,Langley, D.B.,Juda, G.A.,Shepard, E.M.,Dooley, D.M.,Freeman, H.C.,Guss, J.M. (登録日: 2004-08-11, 公開日: 2005-12-08, 最終更新日: 2025-07-30)

主引用文献

Langley, D.B.,Trambaiolo, D.M.,Duff, A.P.,Dooley, D.M.,Freeman, H.C.,Guss, J.M.
Complexes of the Copper-Containing Amine Oxidase from Arthrobacter Globiformis with the Inhibitors Benzylhydrazine and Tranylcypromine.
Acta Crystallogr.,Sect.F, 64:577-, 2008

PubMed Abstract: Complexes of Arthrobacter globiformis amine oxidase (AGAO) with the inhibitors benzylhydrazine and tranylcypromine (an antidepressant drug) have been refined at 1.86 and 1.65 A resolution, respectively. Both inhibitors form covalent adducts with the TPQ cofactor. A tyrosine residue, proposed to act as a gate to the AGAO active site, is in its open conformation.

PubMed: 18607080
DOI: 10.1107/S174430910801556X

実験手法

X-RAY DIFFRACTION (1.86 Å)