1W0I

Arabidopsis thaliana Mitochondrial KAS

1W0I の概要

• エントリーDOI: 10.2210/pdb1w0i/pdb
• 分子名称: 3-OXOACYL CARRIER PROTEIN SYNTHASE, POTASSIUM ION, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: beta-ketoacyl-(acyl carrier protein) synthase, condensing enzyme, fatty acid elongation, lipid metabolism, synthase
• 由来する生物種: ARABIDOPSIS THALIANA (MOUSE-EAR CRESS)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 92292.56

構造登録者

Olsen, J.G.,Rasmussen, A.V.,von Wettstein-Knowles, P.,Henriksen, A. (登録日: 2004-06-04, 公開日: 2004-11-10, 最終更新日: 2023-12-13)

主引用文献

Olsen, J.G.,Rasmussen, A.V.,von Wettstein-Knowles, P.,Henriksen, A.
Structure of the mitochondrial beta-ketoacyl-[acyl carrier protein] synthase from Arabidopsis and its role in fatty acid synthesis.
FEBS Lett., 577:170-174, 2004

PubMed Abstract: Mitochondrial fatty acid synthesis is catalyzed by a dissociated fatty acid synthase similar to those of plant plastids and bacteria. The crystal structure of a mitochondrial beta-ketoacyl-[acyl carrier protein] synthase (mtKAS), namely that from Arabidopsis thaliana, has been determined for the first time. This enzyme accomplishes the vital condensation steps in constructing fatty acid carbon skeletons. The product profile of mtKAS is unusual in that C8 and C(14-16) fatty acyl chains predominate. An enzyme architecture that likely is the basis for the observed bimodal profile of mtKAS products can be derived from the shape of the acyl binding pocket.

PubMed: 15527780
DOI: 10.1016/j.febslet.2004.10.007

実験手法

X-RAY DIFFRACTION (2.1 Å)