1VXR
O-ETHYLMETHYLPHOSPHONYLATED ACETYLCHOLINESTERASE OBTAINED BY REACTION WITH O-ETHYL-S-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL] METHYLPHOSPHONOTHIOATE (VX)
Summary for 1VXR
Entry DOI | 10.2210/pdb1vxr/pdb |
Descriptor | PROTEIN (ACETYLCHOLINESTERASE), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | cholinesterase, organophosphate, serine hydrolase, chemical-warfare, hydrolase |
Biological source | Torpedo californica (Pacific electric ray) |
Cellular location | Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058 |
Total number of polymer chains | 1 |
Total formula weight | 61896.68 |
Authors | Millard, C.B.,Koellner, G.,Silman, I.,Sussman, J.L. (deposition date: 1999-04-21, release date: 1999-11-15, Last modification date: 2023-08-23) |
Primary citation | Millard, C.B.,Koellner, G.,Ordentlich, A.,Shafferman, A.,Silman, I.,Sussman, J.L. Reaction Products of Acetylcholinesterase and VX Reveal a Mobile Histidine in the Catalytic Triad J.Am.Chem.Soc., 121:9883-9884, 1999 Cited by DOI: 10.1021/ja992704iPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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