1VTY

Crystal structure of a Z-DNA fragment containing thymine/2-aminoadenine base pairs

Summary for 1VTY

• Entry DOI: 10.2210/pdb1vty/pdb
• Descriptor: DNA (5'-D(*CP*(NH2)AP*CP*GP*TP*G)-3'), AMINO GROUP, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: z-dna, double helix, modified, dna
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 3704.81

Authors

Coll, M.,Wang, A.H.-J.,Van Der Marel, G.A.,Van Boom, J.H.,Rich, A. (deposition date: 1988-08-18, release date: 2011-07-13, Last modification date: 2023-12-27)

Primary citation

Coll, M.,Wang, A.H.,van der Marel, G.A.,van Boom, J.H.,Rich, A.
Crystal structure of a Z-DNA fragment containing thymine/2-aminoadenine base pairs.
J. Biomol. Struct. Dyn., 4:157-172, 1986

PubMed Abstract: The Z-DNA structure has been shown to form in two crystals made from self-complementary DNA hexamers d(CGTDCG) and d(CDCGTG) which contain thymine/2-aminoadenine (TD) base pairs. The latter structure has been solved and refined to 1.3 A resolution and it shows only small conformational changes due to the introduction of the TD base pairs in comparison with the structure of d(CG)3. Spectroscopic studies with these compounds demonstrate that DNA molecules containing 2-aminoadenine residues form Z-DNA slightly more easily than do those containing adenine nucleotides, but not as readily as the parent sequence containing only guanine-cytosine base pairs.

PubMed: 3271437
DOI: 10.1080/07391102.1986.10506337

Experimental method

X-RAY DIFFRACTION (1.3 Å)