1VTY

Crystal structure of a Z-DNA fragment containing thymine/2-aminoadenine base pairs

1VTY の概要

• エントリーDOI: 10.2210/pdb1vty/pdb
• 分子名称: DNA (5'-D(*CP*(NH2)AP*CP*GP*TP*G)-3'), AMINO GROUP, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: z-dna, double helix, modified, dna
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 3704.81

構造登録者

Coll, M.,Wang, A.H.-J.,Van Der Marel, G.A.,Van Boom, J.H.,Rich, A. (登録日: 1988-08-18, 公開日: 2011-07-13, 最終更新日: 2023-12-27)

主引用文献

Coll, M.,Wang, A.H.,van der Marel, G.A.,van Boom, J.H.,Rich, A.
Crystal structure of a Z-DNA fragment containing thymine/2-aminoadenine base pairs.
J. Biomol. Struct. Dyn., 4:157-172, 1986

PubMed Abstract: The Z-DNA structure has been shown to form in two crystals made from self-complementary DNA hexamers d(CGTDCG) and d(CDCGTG) which contain thymine/2-aminoadenine (TD) base pairs. The latter structure has been solved and refined to 1.3 A resolution and it shows only small conformational changes due to the introduction of the TD base pairs in comparison with the structure of d(CG)3. Spectroscopic studies with these compounds demonstrate that DNA molecules containing 2-aminoadenine residues form Z-DNA slightly more easily than do those containing adenine nucleotides, but not as readily as the parent sequence containing only guanine-cytosine base pairs.

PubMed: 3271437
DOI: 10.1080/07391102.1986.10506337

実験手法

X-RAY DIFFRACTION (1.3 Å)