1VTX

DELTA-ATRACOTOXIN-HV1 (VERSUTOXIN) FROM HADRONYCHE VERSUTA, NMR, 20 STRUCTURES

1VTX の概要

• エントリーDOI: 10.2210/pdb1vtx/pdb
• 分子名称: DELTA-ATRACOTOXIN-HV1 (1 entity in total)
• 機能のキーワード: neurotoxin, sodium channel toxin, cysteine knot, venom
• 由来する生物種: Hadronyche versuta
• 細胞内の位置: Secreted: P13494
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4862.72

構造登録者

Fletcher, J.I.,Chapman, B.E.,King, G.F. (登録日: 1997-03-13, 公開日: 1998-01-28, 最終更新日: 2024-11-20)

主引用文献

Fletcher, J.I.,Chapman, B.E.,Mackay, J.P.,Howden, M.E.,King, G.F.
The structure of versutoxin (delta-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel.
Structure, 5:1525-1535, 1997

PubMed Abstract: Versutoxin (delta-ACTX-Hv1) is the major component of the venom of the Australian Blue Mountains funnel web spider, Hadronyche versuta. delta-ACTX-Hv1 produces potentially fatal neurotoxic symptoms in primates by slowing the inactivation of voltage-gated sodium channels; delta-ACTX-Hv1 is therefore a useful tool for studying sodium channel function. We have determined the three-dimensional structure of delta-ACTX-Hv1 as the first step towards understanding the molecular basis of its interaction with these channels.

PubMed: 9384567
DOI: 10.1016/S0969-2126(97)00301-8

実験手法

SOLUTION NMR