1VTN

CO-CRYSTAL STRUCTURE OF THE HNF-3/FORK HEAD DNA-RECOGNITION MOTIF RESEMBLES HISTONE H5

Summary for 1VTN

• Entry DOI: 10.2210/pdb1vtn/pdb
• Descriptor: DNA (5'-D(*GP*AP*CP*TP*AP*AP*GP*TP*CP*AP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*TP*GP*AP*CP*TP*TP*AP*GP*TP*C)-3'), HNF-3/FORK HEAD DNA-RECOGNITION MOTIF, ... (5 entities in total)
• Functional Keywords: protein-dna complex, double helix, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 20018.38

Authors

Clark, K.L.,Halay, E.D.,Lai, E.,Burley, S.K. (deposition date: 1995-01-06, release date: 2011-07-13, Last modification date: 2023-12-27)

Primary citation

Clark, K.L.,Halay, E.D.,Lai, E.,Burley, S.K.
Co-Crystal Structure of the HNF-3/Fork Head DNA-Recognition Motif Resembles Histone H5
Nature, 364:412-420, 1993

PubMed Abstract: The three-dimensional structure of an HNF-3/fork head DNA-recognition motif complexed with DNA has been determined by X-ray crystallography at 2.5 A resolution. This alpha/beta protein binds B-DNA as a monomer, through interactions with the DNA backbone and through both direct and water-mediated major and minor groove base contacts, inducing a 13 degrees bend. The transcription factor fold is very similar to the structure of histone H5. In its amino-terminal half, three alpha-helices adopt a compact structure that presents the third helix to the major groove. The remainder of the protein includes a twisted, antiparallel beta-structure and random coil that interacts with the minor groove.

PubMed: 8332212
DOI: 10.1038/364412a0

Experimental method

X-RAY DIFFRACTION (2.5 Å)