1VSC

VCAM-1

1VSC の概要

• エントリーDOI: 10.2210/pdb1vsc/pdb
• 分子名称: VASCULAR CELL ADHESION MOLECULE-1 (2 entities in total)
• 機能のキーワード: cell adhesion protein, immunoglobulin fold, glycoprotein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P19320
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43691.50

構造登録者

Wang, J.,Stehle, T.,Osborn, L. (登録日: 1995-04-27, 公開日: 1996-06-20, 最終更新日: 2024-10-23)

主引用文献

Wang, J.H.,Pepinsky, R.B.,Stehle, T.,Liu, J.H.,Karpusas, M.,Browning, B.,Osborn, L.
The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction.
Proc.Natl.Acad.Sci.USA, 92:5714-5718, 1995

PubMed Abstract: Vascular cell adhesion molecule 1 (VCAM-1) represents a structurally and functionally distinct class of immunoglobulin superfamily molecules that bind leukocyte integrins and are involved in inflammatory and immune functions. X-ray crystallography defines the three-dimensional structure of the N-terminal two-domain fragment that participates in ligand binding. Residues in domain 1 important for ligand binding reside in the C-D loop, which projects markedly from one face of the molecule near the contact between domains 1 and 2. A cyclic peptide that mimics this loop inhibits binding of alpha 4 beta 1 integrin-bearing cells to VCAM-1. These data demonstrate how crystallographic structural information can be used to design a small molecule inhibitor of biological function.

PubMed: 7539925
DOI: 10.1073/pnas.92.12.5714

実験手法

X-RAY DIFFRACTION (1.9 Å)