1VOK

ARABIDOPSIS THALIANA TBP (DIMER)

1VOK の概要

• エントリーDOI: 10.2210/pdb1vok/pdb
• 分子名称: TATA-BOX-BINDING PROTEIN, SULFATE ION (3 entities in total)
• 機能のキーワード: transcription initiation, dna binding, transcription factor
• 由来する生物種: Arabidopsis thaliana (thale cress)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44896.77

構造登録者

Nikolov, D.B.,Burley, S.K. (登録日: 1996-04-29, 公開日: 1996-11-08, 最終更新日: 2024-02-14)

主引用文献

Nikolov, D.B.,Burley, S.K.
2.1 A resolution refined structure of a TATA box-binding protein (TBP).
Nat.Struct.Biol., 1:621-637, 1994

PubMed Abstract: The three-dimensional structure of a TATA box-binding protein (TBP2) from Arabidopsis thaliana has been refined at 2.1 A resolution. TBPs are general eukaryotic transcription factors that participate in initiation of RNA synthesis by all three eukaryotic RNA polymerases. The carboxy-terminal portion of TBP is a unique DNA-binding motif/protein fold, adopting a highly symmetric alpha/beta structure that resembles a molecular saddle with two stirrup-like loops. A ten-stranded, antiparallel beta-sheet provides a concave surface for recognizing class II nuclear gene promoters, while the four amphipathic alpha-helices on the convex surface are available for interaction with other transcription factors. The myriad interactions of TBP2 with components of the transcription machinery are discussed.

PubMed: 7634102
DOI: 10.1038/nsb0994-621

実験手法

X-RAY DIFFRACTION (2.1 Å)