1VJ3
STRUCTURAL STUDIES ON BIO-ACTIVE COMPOUNDS. CRYSTAL STRUCTURE AND MOLECULAR MODELING STUDIES ON THE PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COFACTOR COMPLEX WITH TAB, A HIGHLY SELECTIVE ANTIFOLATE.
Replaces: 1D8RSummary for 1VJ3
| Entry DOI | 10.2210/pdb1vj3/pdb |
| Descriptor | DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ACETIC ACID N-[2-CHLORO-5-[6-ETHYL-2,4-DIAMINO-PYRIMID-5-YL]-PHENYL]-[BENZYL-TRIAZEN-3-YL]ETHYL ESTER, ... (4 entities in total) |
| Functional Keywords | tab, nadph, molecular modeling, oxidoreductase |
| Biological source | Pneumocystis carinii |
| Total number of polymer chains | 1 |
| Total formula weight | 25000.71 |
| Authors | Cody, V.,Galitsky, N.,Rak, D.,Luft, J.R.,Queener, S.F.,Laughton, C.A.,Malcolm, F.G. (deposition date: 2004-01-13, release date: 2004-01-20, Last modification date: 2023-12-27) |
| Primary citation | Cody, V.,Chan, D.,Galitsky, N.,Rak, D.,Luft, J.R.,Pangborn, W.,Queener, S.F.,Laughton, C.A.,Stevens, M.F. Structural studies on bioactive compounds. 30. Crystal structure and molecular modeling studies on the Pneumocystis carinii dihydrofolate reductase cofactor complex with TAB, a highly selective antifolate. Biochemistry, 39:3556-3564, 2000 Cited by PubMed: 10736154DOI: 10.1021/bi9924563 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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