1VIK

HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 ORTHORHOMBIC FORM

Summary for 1VIK

• Entry DOI: 10.2210/pdb1vik/pdb
• Descriptor: HIV-1 PROTEASE, N-(1-BENZYL-2,3-DIHYDROXY-4-{3-METHYL-2-[2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYLAMINO]-BUTYRYLAMINO}-5-PHENYL-PENTYL)-3-METHYL-2-[2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYLAMINO]-BUTYRAMIDE (3 entities in total)
• Functional Keywords: aspartyl protease, human immunodeficiency virus, hoe/bay 793: inhibitor design
• Biological source: Human immunodeficiency virus 1
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12499
• Total number of polymer chains: 2
• Total formula weight: 22793.05

Authors

Lange-Savage, G.,Berchtold, H.,Liesum, A.,Hilgenfeld, R. (deposition date: 1997-05-07, release date: 1998-12-09, Last modification date: 2024-02-14)

• Primary citation: Lange-Savage, G.,Berchtold, H.,Liesum, A.,Budt, K.H.,Peyman, A.,Knolle, J.,Sedlacek, J.,Fabry, M.,Hilgenfeld, R.; Structure of HOE/BAY 793 complexed to human immunodeficiency virus (HIV-1) protease in two different crystal forms--structure/function relationship and influence of crystal packing.; Eur.J.Biochem., 248:313-322, 1997; PubMed: 9346283; DOI: 10.1111/j.1432-1033.1997.00313.x

Experimental method

X-RAY DIFFRACTION (2.4 Å)