1VID

CATECHOL O-METHYLTRANSFERASE

1VID の概要

• エントリーDOI: 10.2210/pdb1vid/pdb
• 分子名称: CATECHOL O-METHYLTRANSFERASE, MAGNESIUM ION, S-ADENOSYLMETHIONINE, ... (5 entities in total)
• 機能のキーワード: transferase, methyltransferase, neurotransmitter degradation, transferase (methyltransferase)
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25395.25

構造登録者

Vidgren, J.,Svensson, L.A.,Liljas, A. (登録日: 1996-01-05, 公開日: 1996-07-11, 最終更新日: 2024-02-14)

主引用文献

Vidgren, J.,Svensson, L.A.,Liljas, A.
Crystal structure of catechol O-methyltransferase.
Nature, 368:354-358, 1994

PubMed Abstract: Catechol O-methyltransferase (COMT, EC 2.1.1.6) is important in the central nervous system because it metabolizes catecholamine neurotransmitters such as dopamine. The enzyme catalyses the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to one hydroxyl group of catechols. COMT also inactivates catechol-type compounds such as L-DOPA. With selective inhibitors of COMT in combination with L-DOPA, a new principle has been realized in the therapy of Parkinson's disease. Here we solve the atomic structure of COMT to 2.0 A resolution, which provides new insights into the mechanism of the methyl transfer reaction. The co-enzyme-binding domain is strikingly similar to that of an AdoMet-dependent DNA methylase, indicating that all AdoMet methylases may have a common structure.

PubMed: 8127373
DOI: 10.1038/368354a0

実験手法

X-RAY DIFFRACTION (2 Å)