1VEX

F-spondin TSR domain 4

1VEX の概要

• エントリーDOI: 10.2210/pdb1vex/pdb
• NMR情報: BMRB: 10002
• 分子名称: F-spondin (1 entity in total)
• 機能のキーワード: f-spondin, tsr, cell adhesion
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix: P35446
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 6240.19

構造登録者

Paakkonen, K.,Tossavainen, H.,Permi, P.,Kilpelainen, I.,Guntert, P. (登録日: 2004-04-06, 公開日: 2005-04-19, 最終更新日: 2024-11-13)

主引用文献

Paakkonen, K.,Tossavainen, H.,Permi, P.,Rakkolainen, H.,Rauvala, H.,Raulo, E.,Kilpelainen, I.,Guntert, P.
Solution structures of the first and fourth TSR domains of F-spondin
Proteins, 64:665-672, 2006

PubMed Abstract: F-spondin is a protein mainly associated with neuronal development. It attaches to the extracellular matrix and acts in the axon guidance of the developing nervous system. F-spondin consists of eight domains, six of which are TSR domains. The TSR domain family binds a wide range of targets. Here we present the NMR solution structures of TSR1 and TSR4. TSR domains have an unusual fold that is characterized by a long, nonglobular shape, consisting of two beta-strands and one irregular extended strand. Three disulfide bridges and stack of alternating tryptophan and arginine side-chains stabilize the structure. TSR1 and TSR4 structures are similar to each other and to the previously determined TSR domain X-ray structures from another protein, TSP, although TSR4 exhibits a mobile loop not seen in other structures.

PubMed: 16736493
DOI: 10.1002/prot.21030

実験手法

SOLUTION NMR