1VCJ

Influenza B virus neuraminidase complexed with 1-(4-Carboxy-2-(3-pentylamino)phenyl)-5-aminomethyl-5-hydroxymethyl-pyrrolidin-2-one

Replaces:  1UJA

Summary for 1VCJ

• Entry DOI: 10.2210/pdb1vcj/pdb
• Descriptor: NEURAMINIDASE, 4-[(2R)-2-(AMINOMETHYL)-2-(HYDROXYMETHYL)-5-OXOPYRROLIDIN-1-YL]-3-[(1-ETHYLPROPYL)AMINO]BENZOIC ACID (3 entities in total)
• Functional Keywords: neuraminidase, benzoic acid inhibitors, small molecule inhibitor, protein-inhibitor complex, hydrolase
• Biological source: Influenza B virus (B/Lee/40)
• Cellular location: Virion membrane (By similarity): P03474
• Total number of polymer chains: 1
• Total formula weight: 43680.66

Authors

Lommer, B.S.,Ali, S.M.,Bajpai, S.N.,Brouillette, W.J.,Air, G.M.,Luo, M. (deposition date: 2004-03-09, release date: 2004-03-23, Last modification date: 2023-12-27)

• Primary citation: Lommer, B.S.,Ali, S.M.,Bajpai, S.N.,Brouillette, W.J.,Air, G.M.,Luo, M.; A benzoic acid inhibitor induces a novel conformational change in the active site of Influenza B virus neuraminidase.; Acta Crystallogr.,Sect.D, 60:1017-1023, 2004; PubMed: 15159560; DOI: 10.1107/S0907444904006225

Experimental method

X-RAY DIFFRACTION (2.4 Å)