1V3X

Factor Xa in complex with the inhibitor 1-[6-methyl-4,5,6,7-tetrahydrothiazolo(5,4-c)pyridin-2-yl] carbonyl-2-carbamoyl-4-(6-chloronaphth-2-ylsulphonyl)piperazine

1V3X の概要

• エントリーDOI: 10.2210/pdb1v3x/pdb
• 関連するPDBエントリー: 1fax 1xka
• 分子名称: Coagulation factor X, HEAVY CHAIN, Coagulation factor X, LIGHT CHAIN, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00742 P00742
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32549.44

構造登録者

Suzuki, M. (登録日: 2003-11-07, 公開日: 2004-11-07, 最終更新日: 2023-10-25)

• 主引用文献: Haginoya, N.,Kobayashi, S.,Komoriya, S.,Yoshino, T.,Suzuki, M.,Shimada, T.,Watanabe, K.,Hirokawa, Y.,Furugori, T.,Nagahara, T.; Synthesis and conformational analysis of a non-amidine factor Xa inhibitor that incorporates 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 binding element; J.Med.Chem., 47:5167-5182, 2004; PubMed: 15456260; DOI: 10.1021/jm049884d

実験手法

X-RAY DIFFRACTION (2.2 Å)