1V3C

Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III: complex with NEU5AC

1V3C の概要

• エントリーDOI: 10.2210/pdb1v3c/pdb
• 関連するPDBエントリー: 1V2I 1V3B 1V3D 1V3E
• 分子名称: hemagglutinin-neuraminidase glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: piv3 hn, native+neu5ac, hexagonal, hydrolase
• 由来する生物種: Human parainfluenza virus 3
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 98810.80

構造登録者

Lawrence, M.C.,Borg, N.A.,Streltsov, V.A.,Pilling, P.A.,Epa, V.C.,Varghese, J.N.,McKimm-Breschkin, J.L.,Colman, P.M. (登録日: 2003-10-30, 公開日: 2004-02-03, 最終更新日: 2024-10-09)

主引用文献

Lawrence, M.C.,Borg, N.A.,Streltsov, V.A.,Pilling, P.A.,Epa, V.C.,Varghese, J.N.,McKimm-Breschkin, J.L.,Colman, P.M.
Structure of the Haemagglutinin-neuraminidase from Human Parainfluenza Virus Type III
J.Mol.Biol., 335:1343-1357, 2004

PubMed Abstract: The three-dimensional structure of the haemagglutinin-neuraminidase (HN) from a human parainfluenza virus is described at ca 2.0 A resolution, both in native form and in complex with three substrate analogues. In support of earlier work on the structure of the homologous protein from the avian pathogen Newcastle disease virus (NDV), we observe a dimer of beta-propellers and find no evidence for spatially separated sites performing the receptor-binding and neuraminidase functions of the protein. As with the NDV HN, the active site of the HN of parainfluenza viruses is structurally flexible, suggesting that it may be able to switch between a receptor-binding state and a catalytic state. However, in contrast to the NDV structures, we observe no ligand-induced structural changes that extend beyond the active site and modify the dimer interface.

PubMed: 14729348
DOI: 10.1016/j.jmb.2003.11.032

実験手法

X-RAY DIFFRACTION (2.3 Å)