1V1R

CROSSTALK BETWEEN COFACTOR BINDING AND THE PHOSPHORYLATION LOOP CONFORMATION IN THE BCKD MACHINE

1V1R の概要

• エントリーDOI: 10.2210/pdb1v1r/pdb
• 関連するPDBエントリー: 1DTW 1OLS 1OLU 1OLX 1V11 1V16 1V1M
• 分子名称: 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, CHLORIDE ION, ... (8 entities in total)
• 機能のキーワード: oxidoreductase, ketoacid dehydrogenase, multi-enzyme complex, acylation, oxidative decarboxylation, maple syrup urine disease, thiamin diphosphate, phosphorylation, flavoprotein
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83917.09

構造登録者

Li, J.,Wynn, R.M.,Machius, M.,Chuang, J.L.,Karthikeyan, S.,Tomchick, D.R.,Chuang, D.T. (登録日: 2004-04-22, 公開日: 2004-06-03, 最終更新日: 2023-12-13)

• 主引用文献: Li, J.,Wynn, R.M.,Machius, M.,Chuang, J.L.,Karthikeyan, S.,Tomchick, D.R.,Chuang, D.T.; Cross-Talk between Thiamin Diphosphate Binding and Phosphorylation Loop Conformation in Human Branched-Chain {Alpha}-Keto Acid Decarboxylase/Dehydrogenase; J.Biol.Chem., 279:32968-, 2004; PubMed: 15166214; DOI: 10.1074/JBC.M403611200

実験手法

X-RAY DIFFRACTION (1.8 Å)