1V1M

CROSSTALK BETWEEN COFACTOR BINDING AND THE PHOSPHORYLATION LOOP CONFORMATION IN THE BCKD MACHINE

1V1M の概要

• エントリーDOI: 10.2210/pdb1v1m/pdb
• 関連するPDBエントリー: 1DTW 1OLS 1OLU 1OLX 1V11 1V16 1V1R
• 分子名称: 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, THIAMINE DIPHOSPHATE, ... (9 entities in total)
• 機能のキーワード: oxidoreductase, ketoacid dehydrogenase, branched-chain, multi-enzyme complex, acylation, oxidative decarboxylation maple syrup urine disease, thiamine diphosphate, phosphorylation, flavoprotein
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 84407.53

構造登録者

Li, J.,Wynn, R.M.,Machius, M.,Chuang, J.L.,Karthikeyan, S.,Tomchick, D.R.,Chuang, D.T. (登録日: 2004-04-20, 公開日: 2004-06-03, 最終更新日: 2023-12-13)

• 主引用文献: Li, J.,Wynn, R.M.,Machius, M.,Chuang, J.L.,Karthikeyan, S.,Tomchick, D.R.,Chuang, D.T.; Cross-Talk between Thiamin Diphosphate Binding and Phosphorylation Loop Conformation in Human Branched-Chain Alpha-Keto Acid Decarboxylase/Dehydrogenase.; J.Biol.Chem., 279:32968-, 2004; PubMed: 15166214; DOI: 10.1074/JBC.M403611200

実験手法

X-RAY DIFFRACTION (2 Å)