1V1J

Crystal structure of type II Dehydroquintae Dehydratase from Streptomyces coelicolor in complex with 3-fluoro

1V1J の概要

• エントリーDOI: 10.2210/pdb1v1j/pdb
• 関連するPDBエントリー: 1D0I 1GTZ 1GU0 1GU1
• 分子名称: 3-DEHYDROQUINATE DEHYDRATASE, 2-ANHYDRO-3-FLUORO-QUINIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
• 機能のキーワード: dhq, shikimate, dehydroquinase, aromatic amino acid biosynthesis, lyase
• 由来する生物種: STREPTOMYCES COELICOLOR
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 203203.89

構造登録者

Roszak, A.W.,Coggins, J.R.,Lapthorn, A.J. (登録日: 2004-04-16, 公開日: 2005-01-26, 最終更新日: 2023-12-13)

主引用文献

Frederickson, M.,Roszak, A.W.,Coggins, J.R.,Lapthorn, A.J.,Abell, C.
(1R,4S,5R)-3-Fluoro-1,4,5-Trihydroxy-2-Cyclohexene-1-Carboxylic Acid: The Fluoro Analogue of the Enolate Intermediate in the Reaction Catalyzed by Type II Dehydroquinases
Org.Biomol.Chem., 2:1592-, 2004

PubMed Abstract: The fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases has been prepared from naturally occurring (-)-quinic acid over seven steps and has been shown to be the most potent inhibitor reported to date of the type II enzyme from Mycobacterium tuberculosis.

PubMed: 15162210
DOI: 10.1039/B404535A

実験手法

X-RAY DIFFRACTION (2.2 Å)