1USP

Organic Hydroperoxide Resistance Protein from Deinococcus radiodurans

1USP の概要

• エントリーDOI: 10.2210/pdb1usp/pdb
• 分子名称: ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, 2-cys peroxidase
• 由来する生物種: DEINOCOCCUS RADIODURANS; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29820.18

構造登録者

Meunier-Jamin, C.,Kapp, U.,Leonard, G.,McSweeney, S. (登録日: 2003-11-27, 公開日: 2004-04-08, 最終更新日: 2024-10-16)

主引用文献

Meunier-Jamin, C.,Kapp, U.,Leonard, G.,Mcsweeney, S.
The Structure of the Organic Hydroperoxide Resistance Protein from Deinococcus Radiodurans: Do Conformational Changes Facilitate Recycling of the Redox Disulfide?
J.Biol.Chem., 279:25830-, 2004

PubMed Abstract: The three-dimensional structure of the organic hydroperoxide resistance protein (OHRP) from Deinococcus radiodurans as determined using single crystal xray diffraction techniques is reported. Comparison of the structure with that obtained for OHRP from Pseudomonas aeruginosa reveals that the polypeptide chain of OHRPs can adopt two significantly different conformations ("in" and "out") in the region of the active site disulfide moiety. It is postulated that the closed configuration is consistent with efficient catalysis of the reduction of organic hydroperoxides, whereas the open form is required for enzyme recycling. Comparison of the structures of OHRP and that of the osmotically induced protein C (OsmC) from Mycoplasma pneumoniae shows that OHRPs and OsmCs are structurally homologous, perhaps indicating related functions for the two families of proteins.

PubMed: 15054099
DOI: 10.1074/JBC.M312983200

実験手法

X-RAY DIFFRACTION (1.9 Å)