1UPJ

HIV-1 PROTEASE COMPLEX WITH U095438 [3-[1-(4-BROMOPHENYL) ISOBUTYL]-4-HYDROXYCOUMARIN

Summary for 1UPJ

Entry DOI	10.2210/pdb1upj/pdb
Descriptor	HIV-1 PROTEASE, 3-[1-(4-BROMO-PHENYL)-2-METHYL-PROPYL]-4-HYDROXY-CHROMEN-2-ONE (3 entities in total)
Functional Keywords	hydrolase (acid protease)
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
Total number of polymer chains	1
Total formula weight	11177.00
Authors	Watenpaugh, K.D.,Mulichak, A.M.,Janakiraman, M.N. (deposition date: 1996-03-04, release date: 1996-10-14, Last modification date: 2024-04-03)
Primary citation	Thaisrivongs, S.,Watenpaugh, K.D.,Howe, W.J.,Tomich, P.K.,Dolak, L.A.,Chong, K.T.,Tomich, C.C.,Tomasselli, A.G.,Turner, S.R.,Strohbach, J.W.,Mulichak, A.M.,Janakiraman, M.N.,Moon, J.B.,Lynn, J.C.,Horng, M.M.,Hinshaw, R.R.,Curry, K.A.,Rothroc, D.J. Structure-based design of novel HIV protease inhibitors: carboxamide-containing 4-hydroxycoumarins and 4-hydroxy-2-pyrones as potent nonpeptidic inhibitors. J.Med.Chem., 38:3624-3637, 1995 Cited by PubMed: 7658450 DOI: 10.1021/jm00018a023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.22 Å)

Structure validation