1UPJ

HIV-1 PROTEASE COMPLEX WITH U095438 [3-[1-(4-BROMOPHENYL) ISOBUTYL]-4-HYDROXYCOUMARIN

1UPJ の概要

• エントリーDOI: 10.2210/pdb1upj/pdb
• 分子名称: HIV-1 PROTEASE, 3-[1-(4-BROMO-PHENYL)-2-METHYL-PROPYL]-4-HYDROXY-CHROMEN-2-ONE (3 entities in total)
• 機能のキーワード: hydrolase (acid protease)
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11177.00

構造登録者

Watenpaugh, K.D.,Mulichak, A.M.,Janakiraman, M.N. (登録日: 1996-03-04, 公開日: 1996-10-14, 最終更新日: 2024-04-03)

• 主引用文献: Thaisrivongs, S.,Watenpaugh, K.D.,Howe, W.J.,Tomich, P.K.,Dolak, L.A.,Chong, K.T.,Tomich, C.C.,Tomasselli, A.G.,Turner, S.R.,Strohbach, J.W.,Mulichak, A.M.,Janakiraman, M.N.,Moon, J.B.,Lynn, J.C.,Horng, M.M.,Hinshaw, R.R.,Curry, K.A.,Rothroc, D.J.; Structure-based design of novel HIV protease inhibitors: carboxamide-containing 4-hydroxycoumarins and 4-hydroxy-2-pyrones as potent nonpeptidic inhibitors.; J.Med.Chem., 38:3624-3637, 1995; PubMed: 7658450; DOI: 10.1021/jm00018a023

実験手法

X-RAY DIFFRACTION (2.22 Å)