1UOS

The Crystal Structure of the Snake Venom Toxin Convulxin

1UOS の概要

• エントリーDOI: 10.2210/pdb1uos/pdb
• 関連するPDBエントリー: 1UMR
• 分子名称: CONVULXIN ALPHA, CONVULXIN BETA (3 entities in total)
• 機能のキーワード: sugar-binding protein, lectin, convulxin, c-type lectin, snake toxin, gpvi, structural proteomics in europe, spine, structural genomics, sugar binding protein
• 由来する生物種: CROTALUS DURISSUS TERRIFICUS (SOUTH AMERICAN RATTLESNAKE); 詳細
• 細胞内の位置: Secreted: O93426 O93427
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 61555.27

構造登録者

Batuwangala, T.,Leduc, M.,Gibbins, J.M.,Bon, C.,Jones, E.Y. (登録日: 2003-09-22, 公開日: 2003-10-14, 最終更新日: 2024-11-20)

主引用文献

Batuwangala, T.,Leduc, M.,Gibbins, J.M.,Bon, C.,Jones, E.Y.
Structure of the Snake-Venom Toxin Convulxin
Acta Crystallogr.,Sect.D, 60:46-, 2004

PubMed Abstract: Snake venoms contain a number of proteins that interact with components of the haemostatic system that promote or inhibit events leading to blood-clot formation. The snake-venom protein convulxin (Cvx) binds glycoprotein (GP) VI, the platelet receptor for collagen, and triggers signal transduction. Here, the 2.7 A resolution crystal structure of Cvx is presented. In common with other members of this snake-venom protein family, Cvx is an alphabeta-heterodimer and conforms to the C-type lectin-fold topology. Comparison with other family members allows a set of Cvx residues that form a concave surface to be putatively implicated in GPVI binding. Unlike other family members, with the exception of flavocetin-A (FL-A), Cvx forms an (alphabeta)(4) tetramer. This oligomeric structure is consistent with Cvx clustering GPVI molecules on the surface of platelets and as a result promoting signal transduction activity. The Cvx structure and the location of the putative binding sites suggest a model for this multimeric signalling assembly.

PubMed: 14684891
DOI: 10.1107/S0907444903021620

実験手法

X-RAY DIFFRACTION (2.7 Å)