1UML

Crystal structure of adenosine deaminase complexed with a potent inhibitor FR233624

Summary for 1UML

Entry DOI	10.2210/pdb1uml/pdb
Related	1O5R
Descriptor	Adenosine deaminase, ZINC ION, 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, ... (4 entities in total)
Functional Keywords	beta barrel, zinc, hydrolase
Biological source	Bos taurus (cattle)
Cellular location	Cell membrane ; Peripheral membrane protein ; Extracellular side : P56658
Total number of polymer chains	1
Total formula weight	40852.60
Authors	Kinoshita, T. (deposition date: 2003-10-03, release date: 2004-09-21, Last modification date: 2023-12-27)
Primary citation	Terasaka, T.,Kinoshita, T.,Kuno, M.,Seki, N.,Tanaka, K.,Nakanishi, I. Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors J.Med.Chem., 47:3730-3743, 2004 Cited by PubMed: 15239652 DOI: 10.1021/jm0306374 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation