1UK3

Crystal structure of SARS Coronavirus Main Proteinase (3CLpro) At pH7.6

Summary for 1UK3

Related1UK2 1UK4
Descriptor3C-like proteinase (2 entities in total)
Functional Keywordsanti-parallel b-barrel, anti-parallel a-helices, hydrolase
Biological sourceSARS coronavirus
Cellular locationNon-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity) P59641
Total number of polymer chains2
Total molecular weight67753.27
Authors
Yang, H.,Yang, M.,Liu, Y.,Bartlam, M.,Ding, Y.,Lou, Z.,Sun, L.,Zhou, Z.,Ye, S.,Anand, K.,Pang, H.,Gao, G.F.,Hilgenfeld, R.,Rao, Z. (deposition date: 2003-08-14, release date: 2003-11-18, Last modification date: 2011-07-13)
Primary citation
Yang, H.,Yang, M.,Ding, Y.,Liu, Y.,Lou, Z.,Zhou, Z.,Sun, L.,Mo, L.,Ye, S.,Pang, H.,Gao, G.F.,Anand, K.,Bartlam, M.,Hilgenfeld, R.,Rao, Z.
The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100:13190-13195, 2003
PubMed: 14585926 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1835675100
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.247212.3%6.8%6.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution