1UDD

TenA homologue protein from P.horikoshii OT3

1UDD の概要

• エントリーDOI: 10.2210/pdb1udd/pdb
• 分子名称: transcriptional regulator (2 entities in total)
• 機能のキーワード: helix-bundle, lipid binding protein
• 由来する生物種: Pyrococcus horikoshii
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 106482.99

構造登録者

Itou, H.,Yao, M.,Watanabe, N.,Tanaka, I. (登録日: 2003-04-28, 公開日: 2004-06-01, 最終更新日: 2023-12-27)

主引用文献

Itou, H.,Yao, M.,Watanabe, N.,Tanaka, I.
Structure analysis of PH1161 protein, a transcriptional activator TenA homologue from the hyperthermophilic archaeon Pyrococcus horikoshii.
Acta Crystallogr.,Sect.D, 60:1094-1100, 2004

PubMed Abstract: The crystal structure of the Bacillus subtilis TenA-homologue protein PH1161 from the hyperthermophilic archaebacterium Pyrococcus horikoshii was determined. TenA is known to belong to a new family of activators that stimulate the production of extracellular proteases in B. subtilis. A sequence-similarity search revealed that TenA-homologue proteins are widespread in bacteria and archaea, suggesting that this family of proteins plays an essential role in these organisms. In the present study, the first three-dimensional structure of a member of the TenA family of proteins was determined, unexpectedly revealing that the protein has a fold identical to that of haem oxygenase-1. Analysis has also shown that the protein has a unique ligand-binding pocket. Electron density of a bound ligand molecule was observed in this pocket. These results provide a valuable insight into the functional understanding of the TenA family of proteins.

PubMed: 15159569
DOI: 10.1107/S0907444904008522

実験手法

X-RAY DIFFRACTION (2.15 Å)