1UCT

Crystal structure of the extracellular fragment of Fc alpha Receptor I (CD89)

1UCT の概要

• エントリーDOI: 10.2210/pdb1uct/pdb
• 分子名称: Immunoglobulin alpha Fc receptor (2 entities in total)
• 機能のキーワード: beta stands, immune system
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform A. Isoform A. Isoform A. Isoform B: Secreted. Isoform B-delta-S2: Secreted: P24071
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25006.26

構造登録者

Ding, Y.,Xu, G.,Yang, M.,Zhang, W.,Rao, Z. (登録日: 2003-04-21, 公開日: 2003-07-22, 最終更新日: 2024-11-13)

主引用文献

Ding, Y.,Xu, G.,Yang, M.,Yao, M.,Gao, G.F.,Zhang, W.,Rao, Z.
Crystal Structure of the Ectodomain of Human Fc{alpha}RI.
J.Biol.Chem., 278:27966-27970, 2003

PubMed Abstract: Human FcalphaRI (CD89) is the receptor specific for IgA, an immunoglobulin that is abundant in mucosa and is also found in high concentrations in serum. Although FcalphaRI is an immunoglobulin Fc receptor (FcR), it differs in many ways from FcRs for other immunoglobulin classes. The genes of most FcRs are located on chromosome 1 at 1q21-23, whereas FcalphaRI is on chromosome 19, at 19q13.4, a region called the leukocyte receptor complex, because it is clustered with several leukocyte receptor families including killer cell inhibitory receptors (KIRs) and leukocyte Ig-like receptors (LIRs). The amino acid sequence of FcalphaRI shares only 20% homology with other FcRs but it has around 35% homology with its neighboring LIRs and KIRs. In this work, we analyzed the crystal structure of the ectodomain of FcalphaRI and examined structure similarities between FcalphaRI and KIR2DL1, KIR2DL2 and LIR-1. Our data show that FcalphaRI, KIRs, and LIRs share a common hydrophobic core in their interdomain interface, and FcalphaRI is evolutionally closer to LIR than KIR.

PubMed: 12783876
DOI: 10.1074/jbc.C300223200

実験手法

X-RAY DIFFRACTION (2.1 Å)