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1UCP

NMR structure of the PYRIN domain of human ASC

1UCP の概要
エントリーDOI10.2210/pdb1ucp/pdb
NMR情報BMRB: 5780
分子名称Apoptosis-associated speck-like protein containing a CARD (1 entity in total)
機能のキーワードdeath domain fold, apoptosis
由来する生物種Homo sapiens (human)
細胞内の位置Cytoplasm: Q9ULZ3
タンパク質・核酸の鎖数1
化学式量合計10091.67
構造登録者
Liepinsh, E.,Barbals, R.,Dahl, E.,Sharipo, A.,Staub, E.,Otting, G. (登録日: 2003-04-16, 公開日: 2003-11-04, 最終更新日: 2023-12-27)
主引用文献Liepinsh, E.,Barbals, R.,Dahl, E.,Sharipo, A.,Staub, E.,Otting, G.
The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition
J.Mol.Biol., 332:1155-1163, 2003
Cited by
PubMed Abstract: The PYRIN domain is a conserved sequence motif identified in more than 20 human proteins with putative functions in apoptotic and inflammatory signalling pathways. The three-dimensional structure of the PYRIN domain from human ASC was determined by NMR spectroscopy. The structure determination reveals close structural similarity to death domains, death effector domains, and caspase activation and recruitment domains, although the structural alignment with these other members of the death-domain superfamily differs from previously predicted amino acid sequence alignments. Two highly positively and negatively charged surfaces in the PYRIN domain of ASC result in a strong electrostatic dipole moment that is predicted to be present also in related PYRIN domains. These results suggest that electrostatic interactions play an important role for the binding between PYRIN domains. Consequently, the previously reported binding between the PYRIN domains of ASC and ASC2/POP1 or between the zebrafish PYRIN domains of zAsc and Caspy is proposed to involve interactions between helices 2 and 3 of one PYRIN domain with helices 1 and 4 of the other PYRIN domain, in analogy to previously reported homophilic interactions between caspase activation and recruitment domains.
PubMed: 14499617
DOI: 10.1016/j.jmb.2003.07.007
主引用文献が同じPDBエントリー
実験手法
SOLUTION NMR
構造検証レポート
Validation report summary of 1ucp
検証レポート(詳細版)ダウンロードをダウンロード

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件を2025-07-23に公開中

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