1U6O

Mispairing of a Site-Specific Major Groove (2S,3S)-N6-(2,3,4-Trihydroxybutyl)-2-deoxyadenosyl DNA Adduct of Butadiene Diol Epoxide with Deoxyguanosine: Formation of a dA(anti)dG(anti) Pairing Interaction

Summary for 1U6O

• Entry DOI: 10.2210/pdb1u6o/pdb
• Related: 1U6N
• Descriptor: 5'-D(*CP*GP*GP*AP*CP*(2BU)P*AP*GP*AP*AP*G)-3', 5'-D(*CP*TP*TP*CP*TP*GP*GP*TP*CP*CP*G)-3' (2 entities in total)
• Functional Keywords: butadiene, mismatch, ras61, deoxyadenosyl, diol epoxide, dna
• Total number of polymer chains: 2
• Total formula weight: 6836.52

Authors

Scholdberg, T.A.,Nechev, L.N.,Merritt, W.K.,Harris, T.M.,Harris, C.M.,Lloyd, R.S.,Stone, M.P. (deposition date: 2004-07-30, release date: 2004-08-10, Last modification date: 2022-03-02)

• Primary citation: Scholdberg, T.A.,Nechev, L.V.,Merritt, W.K.,Harris, T.M.,Harris, C.M.,Lloyd, R.S.,Stone, M.P.; Mispairing of a Site Specific Major Groove (2S,3S)-N6-(2,3,4-Trihydroxybutyl)-2'-deoxyadenosyl DNA Adduct of Butadiene Diol Epoxide with Deoxyguanosine: Formation of a dA(anti)dG(anti) Pairing Interaction.; CHEM.RES.TOXICOL., 18:145-153, 2005; PubMed: 15720118; DOI: 10.1021/tx049772p

Experimental method

SOLUTION NMR