1TVT

STRUCTURE OF THE EQUINE INFECTIOUS ANEMIA VIRUS TAT PROTEIN

1TVT の概要

• エントリーDOI: 10.2210/pdb1tvt/pdb
• 分子名称: TRANSACTIVATOR PROTEIN (1 entity in total)
• 機能のキーワード: transcription regulation
• 由来する生物種: Equine infectious anemia virus
• 細胞内の位置: Host nucleus, host nucleolus (By similarity): Q9WM01
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 8466.57

構造登録者

Roesch, P.,Willbold, D. (登録日: 1994-07-07, 公開日: 1995-07-10, 最終更新日: 2024-10-16)

主引用文献

Willbold, D.,Rosin-Arbesfeld, R.,Sticht, H.,Frank, R.,Rosch, P.
Structure of the equine infectious anemia virus Tat protein.
Science, 264:1584-1587, 1994

PubMed Abstract: Trans-activator (Tat) proteins regulate the transcription of lentiviral DNA in the host cell genome. These RNA binding proteins participate in the life cycle of all known lentiviruses, such as the human immunodeficiency viruses (HIV) or the equine infectious anemia virus (EIAV). The consensus RNA binding motifs [the trans-activation responsive element (TAR)] of HIV-1 as well as EIAV Tat proteins are well characterized. The structure of the 75-amino acid EIAV Tat protein in solution was determined by two- and three-dimensional nuclear magnetic resonance methods and molecular dynamics calculations. The protein structure exhibits a well-defined hydrophobic core of 15 amino acids that serves as a scaffold for two flexible domains corresponding to the NH2- and COOH-terminal regions. The core region is a strictly conserved sequence region among the known Tat proteins. The structural data can be used to explain several of the observed features of Tat proteins.

PubMed: 7515512

実験手法

SOLUTION NMR