1TVR
HIV-1 RT/9-CL TIBO
Summary for 1TVR
Entry DOI | 10.2210/pdb1tvr/pdb |
Descriptor | REVERSE TRANSCRIPTASE, 4-CHLORO-8-METHYL-7-(3-METHYL-BUT-2-ENYL)-6,7,8,9-TETRAHYDRO-2H-2,7,9A-TRIAZA-BENZO[CD]AZULENE-1-THIONE (3 entities in total) |
Functional Keywords | aids, polyprotein, hydrolase, aspartyl protease, endonuclease, rna-directed dna polymerase, 3hiv-1 rt/9-cl tibo |
Biological source | Human immunodeficiency virus type 1 (CLONE 12) More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
Total number of polymer chains | 2 |
Total formula weight | 114507.88 |
Authors | Das, K.,Ding, J.,Hsiou, Y.,Arnold, E. (deposition date: 1996-04-16, release date: 1997-03-12, Last modification date: 2024-02-14) |
Primary citation | Das, K.,Ding, J.,Hsiou, Y.,Clark Jr., A.D.,Moereels, H.,Koymans, L.,Andries, K.,Pauwels, R.,Janssen, P.A.,Boyer, P.L.,Clark, P.,Smith Jr., R.H.,Kroeger Smith, M.B.,Michejda, C.J.,Hughes, S.H.,Arnold, E. Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant. J.Mol.Biol., 264:1085-1100, 1996 Cited by PubMed: 9000632DOI: 10.1006/jmbi.1996.0698 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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