1TUG

Aspartate Transcarbamoylase Catalytic Chain Mutant E50A Complex with Phosphonoacetamide, Malonate, and Cytidine-5-Prime-Triphosphate (CTP)

Summary for 1TUG

Entry DOI	10.2210/pdb1tug/pdb
Related	1NBE 1TTH 1TU0 3AT1
Descriptor	Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, MALONATE ION, ... (7 entities in total)
Functional Keywords	protein structure-function, site specific mutagenesis, domain closure, allosteric transition, hydrolase-hydrolase regulator complex, hydrolase/hydrolase regulator
Biological source	Escherichia coli More
Total number of polymer chains	4
Total formula weight	104424.71
Authors	Stieglitz, K.,Stec, B.,Baker, D.P.,Kantrowitz, E.R. (deposition date: 2004-06-24, release date: 2004-07-20, Last modification date: 2024-04-03)
Primary citation	Stieglitz, K.,Stec, B.,Baker, D.P.,Kantrowitz, E.R. Monitoring the Transition from the T to the R State in E.coli Aspartate Transcarbamoylase by X-ray Crystallography: Crystal Structures of the E50A Mutant Enzyme in Four Distinct Allosteric States. J.Mol.Biol., 341:853-868, 2004 Cited by PubMed: 15288791 DOI: 10.1016/j.jmb.2004.06.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation