1TTG

THE THREE-DIMENSIONAL STRUCTURE OF THE TENTH TYPE III MODULE OF FIBRONECTIN: AN INSIGHT INTO RGD-MEDIATED INTERACTIONS

1TTG の概要

• エントリーDOI: 10.2210/pdb1ttg/pdb
• 分子名称: FIBRONECTIN (1 entity in total)
• 機能のキーワード: glycoprotein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix: P02751
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9947.06

構造登録者

Main, A.L.,Harvey, T.S.,Baron, M.,Campbell, I.D. (登録日: 1993-07-14, 公開日: 1994-01-31, 最終更新日: 2024-05-01)

主引用文献

Main, A.L.,Harvey, T.S.,Baron, M.,Boyd, J.,Campbell, I.D.
The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions.
Cell(Cambridge,Mass.), 71:671-678, 1992

PubMed Abstract: The solution structure of the tenth type III module of fibronectin has been determined using nuclear magnetic resonance techniques. The molecule has a fold similar to that of immunoglobulin domains, with seven beta strands forming two antiparallel beta sheets, which pack against each other. Both beta sheets contribute conserved hydrophobic residues to a compact core. The topology is more similar to that of domain 2 of CD4, PapD, and the extracellular domain of the human growth hormone receptor than to that of immunoglobulin C domains. The module contains an Arg-Gly-Asp sequence known to be involved in cell adhesion. This tripeptide is solvent exposed and lies on a conformationally mobile loop between strands F and G, consistent with its cell adhesion function.

PubMed: 1423622
DOI: 10.1016/0092-8674(92)90600-H

実験手法

SOLUTION NMR