1TSU

CRYSTAL STRUCTURE OF DECAMER NCP1 SUBSTRATE PEPTIDE IN COMPLEX WITH WILD-TYPE D25N HIV-1 PROTEASE VARIANT

1TSU の概要

• エントリーDOI: 10.2210/pdb1tsu/pdb
• 分子名称: Pol polyprotein, NC-P1 SUBSTRATE PEPTIDE (3 entities in total)
• 機能のキーワード: co-evolution, nucleocapdis, substrate recognition, hiv-1 protease, viral protein-hydrolase complex, viral protein/hydrolase
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369; Gag polyprotein: Host cell membrane; Lipid- anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion : P04591
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 22536.64

構造登録者

Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A. (登録日: 2004-06-21, 公開日: 2005-03-29, 最終更新日: 2023-08-23)

• 主引用文献: Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A.; Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease; J.Virol., 78:12446-12454, 2004; PubMed: 15507631; DOI: 10.1128/JVI.78.22.12446-12454.2004

実験手法

X-RAY DIFFRACTION (2.1 Å)