1TSU

CRYSTAL STRUCTURE OF DECAMER NCP1 SUBSTRATE PEPTIDE IN COMPLEX WITH WILD-TYPE D25N HIV-1 PROTEASE VARIANT

1TSU の概要

分子名称Pol polyprotein, NC-P1 SUBSTRATE PEPTIDE (3 entities in total)
機能のキーワードco-evolution, nucleocapdis, substrate recognition, hiv-1 protease, viral protein-hydrolase complex, viral protein/hydrolase
細胞内の位置Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion  P03369
Gag polyprotein: Host cell membrane; Lipid- anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion  P04591
ポリマー鎖数3
分子量合計22536.64
構造登録者
Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A. (登録日: 2004-06-21, 公開日: 2005-03-29, 最終更新日: 2017-10-11)
主引用文献
Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A.
Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease
J.Virol., 78:12446-12454, 2004
PubMed: 15507631 (主引用文献が同じPDBエントリー)
DOI: 10.1128/JVI.78.22.12446-12454.2004
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.1 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers191.0%4.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード