1TSR
P53 CORE DOMAIN IN COMPLEX WITH DNA
Summary for 1TSR
Entry DOI | 10.2210/pdb1tsr/pdb |
Descriptor | DNA (5'-D(*TP*TP*TP*CP*CP*TP*AP*GP*AP*CP*TP*TP*GP*CP*CP*CP*A P*AP*TP*TP*A)-3'), DNA (5'-D(*AP*TP*AP*AP*TP*TP*GP*GP*GP*CP*AP*AP*GP*TP*CP*TP*A P*GP*GP*AP*A)-3'), PROTEIN (P53 TUMOR SUPPRESSOR), ... (5 entities in total) |
Functional Keywords | tumor suppressor, anti-oncogene, antitumor protein-dna complex, antitumor protein/dna |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 5 |
Total formula weight | 86840.24 |
Authors | Cho, Y.,Gorina, S.,Jeffrey, P.,Pavletich, N. (deposition date: 1995-07-28, release date: 1996-01-29, Last modification date: 2024-02-14) |
Primary citation | Cho, Y.,Gorina, S.,Jeffrey, P.D.,Pavletich, N.P. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science, 265:346-355, 1994 Cited by PubMed: 8023157PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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