1TSN
THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH FDUMP AND METHYLENETETRAHYDROFOLATE
Summary for 1TSN
Entry DOI | 10.2210/pdb1tsn/pdb |
Descriptor | THYMIDYLATE SYNTHASE, PHOSPHATE ION, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ... (5 entities in total) |
Functional Keywords | transferase, methyltransferase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 31440.26 |
Authors | Hyatt, D.C.,Maley, F.,Montfort, W.R. (deposition date: 1996-12-02, release date: 1997-07-07, Last modification date: 2024-04-03) |
Primary citation | Hyatt, D.C.,Maley, F.,Montfort, W.R. Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate. Biochemistry, 36:4585-4594, 1997 Cited by PubMed: 9109668DOI: 10.1021/bi962936j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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