1TSN

THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH FDUMP AND METHYLENETETRAHYDROFOLATE

1TSN の概要

• エントリーDOI: 10.2210/pdb1tsn/pdb
• 分子名称: THYMIDYLATE SYNTHASE, PHOSPHATE ION, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: transferase, methyltransferase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31440.26

構造登録者

Hyatt, D.C.,Maley, F.,Montfort, W.R. (登録日: 1996-12-02, 公開日: 1997-07-07, 最終更新日: 2024-04-03)

• 主引用文献: Hyatt, D.C.,Maley, F.,Montfort, W.R.; Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate.; Biochemistry, 36:4585-4594, 1997; PubMed: 9109668; DOI: 10.1021/bi962936j

実験手法

X-RAY DIFFRACTION (2.2 Å)