1TPS

ATOMIC STRUCTURE OF THE TRYPSIN-A90720A COMPLEX: A UNIFIED APPROACH TO STRUCTURE AND FUNCTION

1TPS の概要

• エントリーDOI: 10.2210/pdb1tps/pdb
• 分子名称: TRYPSIN, INHIBITOR A90720A, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Bos taurus (cattle); 詳細
• 細胞内の位置: Secreted, extracellular space: P00760
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 24440.56

構造登録者

Lee, A.Y.,Clardy, J. (登録日: 1994-09-04, 公開日: 1995-01-26, 最終更新日: 2024-06-05)

主引用文献

Lee, A.Y.,Smitka, T.A.,Bonjouklian, R.,Clardy, J.
Atomic structure of the trypsin-A90720A complex: a unified approach to structure and function.
Chem.Biol., 1:113-117, 1994

PubMed Abstract: A90720A is a potent serine proteinase inhibitor produced by the terrestrial blue-green alga Microchaete loktakensis. Most of its structure has been defined by spectroscopic and degradative studies, but the configurations of several stereochemical centers are unknown, and its mode of inhibition of serine proteinases is not understood. We therefore examined the structure of the compound in a complex with trypsin.

PubMed: 9383379
DOI: 10.1016/1074-5521(94)90049-3

実験手法

X-RAY DIFFRACTION (1.9 Å)