1TPG

F1-G MODULE PAIR RESIDUES 1-91 (C83S) OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (T-PA) (NMR, 298K, PH2.95, REPRESENTATIVE STRUCTURE)

1TPG の概要

• エントリーDOI: 10.2210/pdb1tpg/pdb
• 分子名称: T-PLASMINOGEN ACTIVATOR F1-G (1 entity in total)
• 機能のキーワード: plasminogen activation
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space: P00750
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10464.82

構造登録者

Smith, B.O.,Downing, A.K.,Driscoll, P.C.,Dudgeon, T.J.,Campbell, I.D. (登録日: 1995-06-14, 公開日: 1995-09-15, 最終更新日: 2024-10-23)

主引用文献

Smith, B.O.,Downing, A.K.,Driscoll, P.C.,Dudgeon, T.J.,Campbell, I.D.
The solution structure and backbone dynamics of the fibronectin type I and epidermal growth factor-like pair of modules of tissue-type plasminogen activator.
Structure, 3:823-833, 1995

PubMed Abstract: The thrombolytic serine protease tissue-type plasminogen activator (t-PA) is a classical modular protein consisting of three types of domain in addition to the serine protease domain: F1 (homologous to fibronectin type I); G (epidermal growth factor-like) and kringle. Biochemical data suggest that the F1 and G modules play a major role in the binding of t-PA to fibrin and to receptors on hepatocytes.

PubMed: 7582899
DOI: 10.1016/S0969-2126(01)00217-9

実験手法

SOLUTION NMR