1TOB

SACCHARIDE-RNA RECOGNITION IN AN AMINOGLYCOSIDE ANTIBIOTIC-RNA APTAMER COMPLEX, NMR, 7 STRUCTURES

Summary for 1TOB

Entry DOI	10.2210/pdb1tob/pdb
Descriptor	RNA (5'-R(GGCACGAGGUUUAGCUACACUCGUGCC)-3'), 3-ammonio-3-deoxy-alpha-D-glucopyranose, 2,6-diammonio-2,3,6-trideoxy-alpha-D-glucopyranose, ... (4 entities in total)
Functional Keywords	ribonucleic acid, rna
Biological source	synthetic construct
Total number of polymer chains	1
Total formula weight	9133.75
Authors	Jiang, L.,Suri, A.K.,Fiala, R.,Patel, D.J. (deposition date: 1996-12-12, release date: 1997-06-16, Last modification date: 2024-05-01)
Primary citation	Jiang, L.,Suri, A.K.,Fiala, R.,Patel, D.J. Saccharide-RNA recognition in an aminoglycoside antibiotic-RNA aptamer complex. Chem.Biol., 4:35-, 1997 Cited by PubMed Abstract: Aminoglycoside antibiotics are known to target ribosomal, retroviral and catalytic RNAs with high affinity and specificity. Recently, in vitro selection experiments have identified RNA aptamers that bind to aminoglycoside antibiotics with nanomolar affinity and stringent specificity, allowing discrimination between closely related family members. There has, to date, been limited structural information on the molecular basis of such saccharide-RNA recognition. PubMed: 9070426 DOI: 10.1016/S1074-5521(97)90235-0 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation