1TOB

SACCHARIDE-RNA RECOGNITION IN AN AMINOGLYCOSIDE ANTIBIOTIC-RNA APTAMER COMPLEX, NMR, 7 STRUCTURES

1TOB の概要

• エントリーDOI: 10.2210/pdb1tob/pdb
• 分子名称: RNA (5'-R(GGCACGAGGUUUAGCUACACUCGUGCC)-3'), 3-ammonio-3-deoxy-alpha-D-glucopyranose, 2,6-diammonio-2,3,6-trideoxy-alpha-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: ribonucleic acid, rna
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9133.75

構造登録者

Jiang, L.,Suri, A.K.,Fiala, R.,Patel, D.J. (登録日: 1996-12-12, 公開日: 1997-06-16, 最終更新日: 2024-05-01)

主引用文献

Jiang, L.,Suri, A.K.,Fiala, R.,Patel, D.J.
Saccharide-RNA recognition in an aminoglycoside antibiotic-RNA aptamer complex.
Chem.Biol., 4:35-, 1997

PubMed Abstract: Aminoglycoside antibiotics are known to target ribosomal, retroviral and catalytic RNAs with high affinity and specificity. Recently, in vitro selection experiments have identified RNA aptamers that bind to aminoglycoside antibiotics with nanomolar affinity and stringent specificity, allowing discrimination between closely related family members. There has, to date, been limited structural information on the molecular basis of such saccharide-RNA recognition.

PubMed: 9070426
DOI: 10.1016/S1074-5521(97)90235-0

実験手法

SOLUTION NMR