1TNQ

STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH

1TNQ の概要

• エントリーDOI: 10.2210/pdb1tnq/pdb
• 分子名称: TROPONIN-C, CALCIUM ION (2 entities in total)
• 機能のキーワード: ef-hand, calcium-binding protein
• 由来する生物種: Gallus gallus (chicken)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10064.24

構造登録者

Gagne, S.M.,Sykes, B.D. (登録日: 1995-07-07, 公開日: 1995-10-15, 最終更新日: 2024-05-22)

主引用文献

Gagne, S.M.,Tsuda, S.,Li, M.X.,Smillie, L.B.,Sykes, B.D.
Structures of the troponin C regulatory domains in the apo and calcium-saturated states.
Nat.Struct.Biol., 2:784-789, 1995

PubMed Abstract: Regulation of contraction in skeletal muscle occurs through calcium binding to the protein troponin C. The solution structures of the regulatory domain of apo and calcium-loaded troponin C have been determined by multinuclear, multidimensional nuclear magnetic resonance techniques. The structural transition in the regulatory domain of troponin C on calcium binding involves an opening of the structure through large changes in interhelical angles. This leads to the increased exposure of an extensive hydrophobic patch, an event that triggers skeletal muscle contraction.

PubMed: 7552750
DOI: 10.1038/nsb0995-784

実験手法

SOLUTION NMR