1TND

THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S

Summary for 1TND

Entry DOI	10.2210/pdb1tnd/pdb
Descriptor	TRANSDUCIN, MAGNESIUM ION, CACODYLATE ION, ... (5 entities in total)
Functional Keywords	binding protein(gtp)
Biological source	Bos taurus (cattle)
Total number of polymer chains	3
Total formula weight	113936.98
Authors	Noel, J.P.,Hamm, H.E.,Sigler, P.B. (deposition date: 1994-03-31, release date: 1994-07-31, Last modification date: 2024-02-14)
Primary citation	Noel, J.P.,Hamm, H.E.,Sigler, P.B. The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. Nature, 366:654-663, 1993 Cited by PubMed Abstract: The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic studies, suggests: how an activated receptor might open this cleft to allow nucleotide exchange; a mechanism for GTP-induced changes in effector and receptor binding surfaces; and a mechanism for GTPase activity not evident from previous data. PubMed: 8259210 DOI: 10.1038/366654a0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation