1TND

THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S

1TND の概要

• エントリーDOI: 10.2210/pdb1tnd/pdb
• 分子名称: TRANSDUCIN, MAGNESIUM ION, CACODYLATE ION, ... (5 entities in total)
• 機能のキーワード: binding protein(gtp)
• 由来する生物種: Bos taurus (cattle)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 113936.98

構造登録者

Noel, J.P.,Hamm, H.E.,Sigler, P.B. (登録日: 1994-03-31, 公開日: 1994-07-31, 最終更新日: 2024-02-14)

主引用文献

Noel, J.P.,Hamm, H.E.,Sigler, P.B.
The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S.
Nature, 366:654-663, 1993

PubMed Abstract: The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic studies, suggests: how an activated receptor might open this cleft to allow nucleotide exchange; a mechanism for GTP-induced changes in effector and receptor binding surfaces; and a mechanism for GTPase activity not evident from previous data.

PubMed: 8259210
DOI: 10.1038/366654a0

実験手法

X-RAY DIFFRACTION (2.2 Å)