1TIT

TITIN, IG REPEAT 27, NMR, MINIMIZED AVERAGE STRUCTURE

1TIT の概要

• エントリーDOI: 10.2210/pdb1tit/pdb
• 分子名称: TITIN, I27 (1 entity in total)
• 機能のキーワード: muscle protein, immunoglobulin-like domain
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10928.43

構造登録者

Improta, S.,Politou, A.S.,Pastore, A. (登録日: 1996-02-02, 公開日: 1996-07-11, 最終更新日: 2024-05-22)

主引用文献

Improta, S.,Politou, A.S.,Pastore, A.
Immunoglobulin-like modules from titin I-band: extensible components of muscle elasticity.
Structure, 4:323-337, 1996

PubMed Abstract: The giant muscle protein titin forms a filament which spans half of the sarcomere and performs, along its length, quite diverse functions. The region of titin located in the sarcomere I-band is believed to play a major role in extensibility and passive elasticity of muscle. In the I-band, the titin sequence consists mostly of repetitive motifs of tandem immunoglobulin-like (Ig) modules intercalated by a potentially non-globular region. The highly repetitive titin architecture suggests that the molecular basis of its mechanical properties be approached through the characterization of the isolated components of the I-band and their interfaces. In the present paper, we report on the structure determination in solution of a representative Ig module from the I-band (I27) as solved by NMR techniques.

PubMed: 8805538
DOI: 10.1016/S0969-2126(96)00036-6

実験手法

SOLUTION NMR