1TI8

H7 Haemagglutinin

1TI8 の概要

• エントリーDOI: 10.2210/pdb1ti8/pdb
• 分子名称: hemagglutinin, 2-acetamido-2-deoxy-alpha-D-glucopyranose, alpha-D-mannopyranose, ... (6 entities in total)
• 機能のキーワード: h7, haemagglutinin, viral protein
• 由来する生物種: Influenza A virus; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55804.86

構造登録者

Russell, R.J.,Gamblin, S.J.,Haire, L.F.,Stevens, D.J.,Xaio, B.,Ha, Y.,Skehel, J.J. (登録日: 2004-06-02, 公開日: 2005-06-21, 最終更新日: 2024-11-20)

主引用文献

Russell, R.J.,Gamblin, S.J.,Haire, L.F.,Stevens, D.J.,Xiao, B.,Ha, Y.,Skehel, J.J.
H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes.
Virology, 325:287-296, 2004

PubMed Abstract: Comparing the structures of H3, H5 and H9 subtype haemagglutinins, we deduced a structural basis for including all 15 influenza subtypes in four clades. H3, H5 and H9 represent three of these clades; we now report the structure of an H7 HA as a representative of the fourth clade. We confirm the structure of the turn at the N-terminus of the conserved central alpha-helix of HA2, and the combination of ionisable residues near the "fusion peptide" as clade-specific features. We compare the structures of three H1 HAs with H5 HA in the same clade, to refine our previous classification and we confirm the division of the clades into two groups of two. We also show the roles of carbohydrate side chains in the esterase-fusion domain boundaries in the formation of clade-specific structural markers.

PubMed: 15246268
DOI: 10.1016/j.virol.2004.04.040

実験手法

X-RAY DIFFRACTION (3 Å)