1THL

Thermolysin complexed with a novel glutaramide derivative, n-(1-(2(r,s)-carboxy-4-phenylbutyl) cyclopentylcarbonyl)-(s)-tryptophan

1THL の概要

• エントリーDOI: 10.2210/pdb1thl/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000237
• 分子名称: THERMOLYSIN, CALCIUM ION, ZINC ION, ... (5 entities in total)
• 機能のキーワード: metalloproteinase, glutaramide derivative, thermolysin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Bacillus thermoproteolyticus
• 細胞内の位置: Secreted: P00800
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35064.59

構造登録者

Holland, D.R.,Matthews, B.W. (登録日: 1993-11-17, 公開日: 1994-01-31, 最終更新日: 2024-05-22)

• 主引用文献: Holland, D.R.,Barclay, P.L.,Danilewicz, J.C.,Matthews, B.W.,James, K.; Inhibition of Thermolysin and Neutral Endopeptidase 24.11 By a Novel Glutaramide Derivative; X-Ray Structure Determination of the Thermolysin-Inhibitor Complex; Biochemistry, 33:51-56, 1994; PubMed: 8286362; DOI: 10.1021/bi00167a007

実験手法

X-RAY DIFFRACTION (1.7 Å)