1THF

CYCLASE SUBUNIT OF IMIDAZOLEGLYCEROLPHOSPHATE SYNTHASE FROM THERMOTOGA MARITIMA

Summary for 1THF

Entry DOI	10.2210/pdb1thf/pdb
Descriptor	HISF PROTEIN, PHOSPHATE ION (3 entities in total)
Functional Keywords	thermophile, tim-barrel, histidine biosynthesis, lyase, phosphate-binding sites
Biological source	Thermotoga maritima
Cellular location	Cytoplasm: Q9X0C6
Total number of polymer chains	1
Total formula weight	27929.79
Authors	Lang, D.A.,Wilmanns, M. (deposition date: 1998-09-17, release date: 2000-07-14, Last modification date: 2024-02-14)
Primary citation	Lang, D.A.,Obmolova, G.,Thoma, R.,Kirschner, K.,Sterner, R.,Wilmanns, M. Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion. Science, 289:1546-1550, 2000 Cited by PubMed Abstract: The atomic structures of two proteins in the histidine biosynthesis pathway consist of beta/alpha barrels with a twofold repeat pattern. It is likely that these proteins evolved by twofold gene duplication and gene fusion from a common half-barrel ancestor. These ancestral domains are not visible as independent domains in the extant proteins but can be inferred from a combination of sequence and structural analysis. The detection of subdomain structures may be useful in efforts to search genome sequences for functionally and structurally related proteins. PubMed: 10968789 DOI: 10.1126/science.289.5484.1546 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation