1THF

CYCLASE SUBUNIT OF IMIDAZOLEGLYCEROLPHOSPHATE SYNTHASE FROM THERMOTOGA MARITIMA

1THF の概要

• エントリーDOI: 10.2210/pdb1thf/pdb
• 分子名称: HISF PROTEIN, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: thermophile, tim-barrel, histidine biosynthesis, lyase, phosphate-binding sites
• 由来する生物種: Thermotoga maritima
• 細胞内の位置: Cytoplasm: Q9X0C6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27929.79

構造登録者

Lang, D.A.,Wilmanns, M. (登録日: 1998-09-17, 公開日: 2000-07-14, 最終更新日: 2024-02-14)

主引用文献

Lang, D.A.,Obmolova, G.,Thoma, R.,Kirschner, K.,Sterner, R.,Wilmanns, M.
Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion.
Science, 289:1546-1550, 2000

PubMed Abstract: The atomic structures of two proteins in the histidine biosynthesis pathway consist of beta/alpha barrels with a twofold repeat pattern. It is likely that these proteins evolved by twofold gene duplication and gene fusion from a common half-barrel ancestor. These ancestral domains are not visible as independent domains in the extant proteins but can be inferred from a combination of sequence and structural analysis. The detection of subdomain structures may be useful in efforts to search genome sequences for functionally and structurally related proteins.

PubMed: 10968789
DOI: 10.1126/science.289.5484.1546

実験手法

X-RAY DIFFRACTION (1.45 Å)